SPINE: Structural Proteomics IN Europe
In October 2002 the first Europe-wide project to address automated processes for structural biology began. This was a 3-year project funded by the EU FP5 programme called SPINE: Structural Proteomics IN Europe. SPINE, a 'second generation' structural genomics project focused on cutting edge technologies aimed at biomedically relevant targets, and generating a pan-European integration of technologies for biomedically focussed structural proteomics. The SPINE consortium comprised nineteen leading centres in structural biology distributed throughout Europe and was coordinated from Oxford, UK. The structures and biological insights resulting from SPINE were reviewed in Acta Cryst D, Vol 62(10), 2006.
SPINE pushed forward the development of European standards in several areas of HTP methods, notably LIMS and the handling of frozen crystals (http://www.spineurope.org/page.php?page=protocol_vials).
SPINE was a catalyst for the development of a distributed network of laboratories with HTP capability in many countries and set the scene for a subsequent project SPINE2-Complexes, funded through FP6 Framework and the current pan-European structural biology Research Infrastructure, Instruct.
The SPINE project was completed in 2006 and abridged details are now found at the Instruct site at www.structuralbiology.eu.Members of the SPINE consortium and SPINE Congress attendees at Montecatini, Italy, 2005.